Long - range enhancer - promoter interactions :
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منابع مشابه
Long-range enhancer-promoter interactions in the Scr-Antp interval of the Drosophila Antennapedia complex.
Long-range enhancer-promoter interactions are commonly seen in complex genetic loci such as Hox genes and globin genes. In the case of the Drosophila Antennapedia complex, the T1 enhancer bypasses the neighboring ftz gene and interacts with the distant Scr promoter to activate expression in posterior head segments. Previous studies identified a 450-bp promoter-proximal sequence, the tethering e...
متن کاملThe promoter targeting sequence facilitates and restricts a distant enhancer to a single promoter in the Drosophila embryo.
Transcriptional enhancers in large gene complexes activate promoters over huge distances, yet little is known about the mechanism of these long-range interactions. We report that the promoter targeting sequence (PTS) from the Abdominal-B locus of the Drosophila bithorax complex facilitates the activity of a distantly located enhancer in transgenic embryos and that it restricts the enhancer to a...
متن کاملA predictive modeling approach for cell line-specific long-range regulatory interactions
Long range regulatory interactions among distal enhancers and target genes are important for tissue-specific gene expression. Genome-scale identification of these interactions in a cell line-specific manner, especially using the fewest possible datasets, is a significant challenge. We develop a novel computational approach, Regulatory Interaction Prediction for Promoters and Long-range Enhancer...
متن کاملThe LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions.
Lineage-specific transcription factors are critical for long-range enhancer interactions, but direct or indirect contributions of architectural proteins such as CCCTC-binding factor (CTCF) to enhancer function remain less clear. The LDB1 complex mediates enhancer-gene interactions at the β-globin locus through LDB1 self-interaction. We find that an LDB1-bound enhancer upstream of carbonic anhyd...
متن کاملPromoter-proximal tethering elements regulate enhancer-promoter specificity in the Drosophila Antennapedia complex.
Insulator DNAs and promoter competition regulate enhancer-promoter interactions within complex genetic loci. Here we provide evidence for a third mechanism: promoter-proximal tethering elements. The Scr-ftz region of the Antennapedia gene complex includes two known enhancers, AE1 and T1. AE1 selectively interacts with the ftz promoter to maintain pair-rule stripes of ftz expression during gastr...
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تاریخ انتشار 2012